Several kinds of flavonoids that have antibacterial activity are apigenin, galangin, flavon, flavonoid glycoside, isoflavon, flavanon, and chalcones. Moreover, it has been reported that other species were having antibacterial activities. įlavonoids were usually synthesized by plants in reaction to the microbial infection, so therefore it is common if flavonoid were effective antimicrobial substances on various types of microorganisms by in vitro. In fact, Miana leaves have many beneficial such as for boil, ear and eyes inflammation medication, meanwhile its root can be used for diarrhea and stomach ache medication. Generally, Miana leaves consume empirically by society by boil the leaves and is used for drink.
Miana leaves has chemical compound as like flavonoid, polyphenol, tannin, saponin, alkaloid, caffeic acid, rosmarinic acid, p-coumaric acid, gallic acid, quercetin, ethyl acetate, methyl eugenol, eugenol, thymol, phenol, carvacrol, phytosterols, mineral, and essential oil. The shape and color of Miana leaves are varied, and one of them which have medicine beneficial is the brownish red leaves. Miana ( Coleus atropurpureus Benth) is described as ornamental plants which can be used as traditional medicine comes from Southeast Asia. Therefore, it is needed to conduct research aimed to know the beneficial of traditional medicine. Nowadays, there are a lot of traditional medication that used by society, yet it does not support by research studies. In this case, the development of antimicrobial medicine depicted as an important key of advancement in the medication field since it is effective to treat infection, improve life quality and medical field as well as pharmacy industries.
Thus, it has led some experts to invest their knowledge in formulating herbal medication for infection disease in which all elements of society can use the medicine. The prevalence of infection disease is still quite high due to the high cost in its treatment and medication. Then, by mixed poly acrylic acid and calcium chloride using ionic glass method, the nanoparticles would be formed.Ĭonclusion: This research indicated that Miana leaves extract of nanoparticles ointment is safe and did not irritate the skin. In the medicine administration system, nanoparticles has function as carrier by dissolving, trap, encapsulate, and attached the medicine in the matrix. The nanoparticles form proven can improve the stability and medicine’s administration.
Results: The result then revealed that ethanol extract of Miana leaves had antibacterial activities toward Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa. The equality showed that 2,50% of Miana leaves is equal with 1,17% of nanoparticles Miana leaves extract.
The mixture of Poly Acrylic Acid (PAA) and calcium chloride using ionic glass method could change the size of Miana leaves’ ethanol extract to be nanoparticle with the average diameter amounted 89,77 nm. Method: The method used in this research is experiment in which try to change the extract form to be nanoparticles and be compared. Hence, SPSS program using Paired T Test is obtained to know the differences between them. Objective(s): Compared the nanoparticles form of Miana leaves with its extracts, even in single state or ointment preparation.
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